Dealing with depression? You’re not alone. Despite affecting as many as 264 million people around the planet, depression often goes undiagnosed and untreated. It can also take many forms, with symptoms ranging from feelings of sadness to negative changes in behavior and mood. Treatment options today are thankfully bountiful, with access to prescription medications, ongoing talk therapy, and daily lifestyle changes for those in need. That said, depression remains an illness without a cure, which is why some patients turn to cannabis as a plausible alternative or addition to their treatment plans. In general, it appears sativa-dominant strains tend to offer the most relief for symptoms of depression—likely because of their ability to produce uplifting, euphoric feelings in consumers.

Looking forward, future research will inevitably help us better understand the relationship between marijuana and depression. For now, we’ve collected the trusted opinions of Leafly experts, poured over sales charts, and analyzed scores of customer reviews to help us compile a list of the best strains to seek out to send your depression packing.